MOTS-c
$40.00
For research use only. MOTS-c is a 16-amino acid mitochondrial-derived peptide (MDP) encoded within the 12S rRNA region of mitochondrial DNA, supplied for research into mitochondrial-nuclear signaling and metabolic regulation.
| FORM | PURITY |
|---|---|
| Lyophilized Powder | ≥99% (HPLC) |
MOTS-c For Laboratory Research
For In Vitro Research Use Only – Not for Human or Veterinary Application
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a bioactive peptide encoded within the mitochondrial genome — a distinction that places it within the emerging class of mitochondrial-derived peptides (MDPs). At 16 amino acids in length, MOTS-c is one of the smallest known bioactive peptides with demonstrated mitochondrial origin.
Research into MOTS-c has focused on its translocation from mitochondria to the nucleus under metabolic stress conditions, where it is believed to interact with nuclear gene regulatory elements. Studies in controlled laboratory settings have examined its role in AMPK pathway activation, one-carbon metabolism, and folate cycle regulation. Its mitochondrial origin and apparent retrograde signaling behavior make it a unique subject in mitochondrial biology, cellular stress response, and metabolic homeostasis research.
Tested in the USA for research and educational use.
Compound Details
| Full Name | Mitochondrial ORF of the 12S rRNA Type-C |
| CAS Number | 1457482-82-4 |
| Molecular Weight | ~2,174.5 Da |
| Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MRWQEMGYIFYPRKLR) |
| Amino Acids | 16 |
| Origin | Mitochondrial-derived peptide encoded by MT-RNR1 gene |
| Purity | ≥99% by HPLC |
| Appearance | White lyophilized powder |
| Solubility | Sterile water or bacteriostatic water |
| Storage | −20°C long-term; 4°C short-term (≤4 weeks lyophilized) |
| For Use | Laboratory and in vitro research purposes only |
Public Research References
Published Research References
- Lee C, Zeng J, Drew BG, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015;21(3):443–454. PMID: 25738459 →
- Reynolds JC, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun. 2021;12(1):470. PubMed →
- Kumagai H, et al. MOTS-c reduces myostatin and muscle atrophy signaling. Am J Physiol Endocrinol Metab. 2021;321(5):E691–E704. PubMed →
- Zheng Y, Wei Z, Wang T. MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation. Front Endocrinol. 2023;14:1120533. PMC9905433 →
- Lee C, Kim KH, Cohen P. MOTS-c: a novel mitochondrial-derived peptide regulating muscle and fat metabolism. Free Radic Biol Med. 2016;100:182–187. PubMed →
All references are provided for informational purposes. Products are for laboratory and scientific research purposes only. Not for human or animal consumption.
RESEARCH USE ONLY
All products sold by Hive Mind Peptides are intended strictly for laboratory and scientific research purposes only. These materials are not approved by the FDA and are not intended for human or veterinary use, clinical applications, diagnostic procedures, or therapeutic treatment of any kind. You must be 21 years of age or older to purchase.
By purchasing from Hive Mind Peptides, you confirm that you are a qualified researcher and that all materials will be handled solely within an appropriate research environment by personnel who understand the risks, limitations, and regulatory requirements associated with investigational compounds. Products must not be administered to humans or animals, represented as therapeutic agents, or used for any medical purpose.
Use of these materials is entirely at your own risk. Hive Mind Peptides assumes no liability for misuse, unsafe handling, improper application, or any regulatory or compliance issues arising from their use.
